Original articlesDifferences between bulimia nervosa and binge-eating disorder in females with type 1 diabetes: The important role of insulin omission
Introduction
In Japan, as in North America and Europe 1, 2, development of disordered eating is not unusual in young females with type 1 diabetes 3, 4. Although no one questions the devastating effect of eating disorders on the clinical course of diabetes 5, 6, 7, 8, 9, 10, the clinical characteristics of these co-occurring patients have not been sufficiently clarified, making successful intervention exceedingly difficult [11]. Classification according to the severity of psychological/behavioral disturbances and medical consequences may be helpful in gaining a clearer understanding of the problems involved in treating these patients, and, thus, lead to more effective treatments.
The high prevalence of binge eating and its severe influence on metabolic control make it one of the most serious eating problems for type 1 diabetic patients 6, 11, 12. Some binge eating type 1 diabetic patients meet the diagnostic criteria for bulimia nervosa, but others do not, mainly because of the absence of recurrent “inappropriate compensatory behavior in order to prevent weight gain” (ICB) 13, 14. However, there has been little systematic research comparing these two groups. Only Affenito et al. [15] have reported the relationship of subclinical and clinical eating disorders to serum glycosylated hemoglobin (HbA1c) values, but they did not compare the two groups in depth from the psychological/behavioral aspect. Furthermore, they found no significant difference in glycemic control between the two groups. The main purpose of this study, therefore, is to compare females with type 1 diabetes who meet all the diagnostic criteria for bulimia nervosa to others who do not.
Recent research has reported the importance of insulin omission and its relation to disordered eating and poorer medical consequences 9, 16, 17. Insulin omission is often used for the purpose of weight loss by females with type 1 diabetes. DSM-IV diagnostic criteria [14] for bulimia nervosa has, for the first time, accepted insulin omission for ICB, which is necessary for the diagnosis of bulimia nervosa. As there is a broad spectrum of methods for insulin omission, however, the significance of insulin omission varies in individual patients because of differences in such factors as frequency, dose, and motive. Examining these factors in type 1 diabetic patients with eating disorders appears to be important to explore the relationship between the insulin omission and the eating disorder.
Although females with type 1 diabetes and eating disorders seem to have a number of general psychological/behavioral and eating-related problems, there have been few studies comparing the magnitude of the influence of each problem on the medical consequences of their diabetes. There is a good possibility that psychological/behavioral factors proven to be highly associated with poorer glycemic control will become meaningful indices for assessment and treatment.
This study was designed to address the following questions concerning the psychological/behavioral and medical characteristics of females with type 1 diabetes and binge eating:
- 1.
How do those who meet DSM-IV criteria for bulimia nervosa differ from those who do not in terms of disordered eating attitudes and behaviors, general psychological disturbances, and medical consequences of diabetes?
- 2.
Which psychological/behavioral factors are most predictive of elevated HbA1c in females with type 1 diabetes and binge eating?
Section snippets
Method
Subjects included 33 females with type 1 diabetes mellitus and binge eating (age 16–36 years) referred from June 1994 to February 1998 to the Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University for treatment of disordered eating and type 1 diabetes. All had been diagnosed with type 1 diabetes for at least 1 year. Twenty-eight of the 33 patients were referred from the Diabetes Center at Tokyo Women's Medical College and the other five patients were from
Results
As shown in Table I, upon comparison of BN, BED, and control groups, there were no significant differences in mean current age, onset of type 1 diabetes, and duration of type 1 diabetes. When BN and BED groups were compared, BN had significantly earlier onset and longer duration of both type 1 diabetes and binge eating than BED. The BED group had a significantly higher body mass index (BMI) than BN and controls, although all three groups were within the normal range. The BN group was prescribed
Discussion
We found that females with type 1 diabetes and bulimia nervosa according to DSM-IV (BN group) have the most severe psychopathology related to eating disorders, general psychological disturbances, and medical consequences of diabetes, those without eating disorders (control) have the least, and that those with binge-eating disorder (BED group) are between BN and control.
It is noteworthy that, contrary to the findings of a previous study that compared clinical and subclinical eating disorders in
Acknowledgements
The authors thank Drs. Akiko Sato, Takehiro Nozaki, and Jun Nagano and Ms. Midori Simura for their cooperation and statistical consultation on this study.
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