Journal of Psychosomatic Research
Volume 69, Issue 3 , Pages 327-328 , September 2010

Multiple chemical sensitivity is a response to chemicals acting as toxicants via excessive NMDA activity

References 

  1. Meulders A, Fannes S, Van Diest I, De Peuter S, Vansteenwegen D, Van den Bergh O. Resistance to extinction in an odor-20% CO2 inhalation paradigm: further evidenc\e for a symptom learning account of multiple chemical sensitivity. J Psychosom Res. 2010;68:47–56
  2. Pall ML. Multiple chemical sensitivity: toxicological questions and mechanisms. Chapter in general and applied toxicology. In:  Ballantyne B,  Marrs TC,  Syversen T editor. 3rd ed. London: John Wiley & Sons; 2009;p. 2303–2352
  3. Pall ML. Explaining “Unexplained Illnesses”: Disease paradigm for chronic fatigue syndrome, multiple chemical sensitivity, fibromylagia, post-traumatic stress disorder, Gulf War syndrome and others. New York: Harrington Park (Haworth) Press; 2007;
  4. Pall ML, Anderson JH. The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensitivity. Arch Environ Health. 2004;59:363–372
  5. Pall ML. NMDA sensitization and stimulation by peroxynitrite, nitric oxide and organic solvents at the mechanism of chemical sensitivity in multiple chemical sensitivity. FASEB J. 2002;16:1407–1417
  6. Pall ML. Elevated nitric oxide/peroxynitrite theory of multiple chemical sensitivity: central role of N-methyl-d-aspartate receptors in the sensitivity mechanism. Environ Health Perspect. 2003;111:1461–1464
  7. Haley RW, Billecke S, La Du BN. Association of low PON1 type Q (type A) arylesterase activity with neurologic symptom complexes in Gulf War veterans. Toxicol Appl Pharmacol. 1999;157:227–233
  8. McKeown-Eyssen G, Baines C, Cole DE, Riley N, Tyndale RF, Marshall L, et al. Case-control study of genotypes in multiple chemical sensitivity: CYP2D6, NAT1, NAT2, PON1, PON2 and MTHFR. Int J Epidemiol. 2004;33:971–978
  9. Schnakenberg E, Fabig KR, Stanulla M, Strobl N, Lustig M, Fabig N, et al. A cross-sectional study of self-reported chemical-related sensitivity is associated with gene variants of drug-metabolizing enzymes. Environ Health. 2007;6:6–16
  10. Müller KE, Schnakenberg E. Die Bedeutung der Glukuronidierung bei umweltmedizinischen Erkrankungen am Beispiel der UDP-glukuronosyltransferase 1A1. Umwelt Medizin Gesellschaft. 2008;21:295–300
  11. Hillert L, Musabasic V, Berglund H, Ciumas C, Savic I. Odor processing in multiple chemical sensitivity. Hum Brain Mapp. 2007;28:172–182
  12. Pall ML. Do sauna therapy and exercise act by raising the availability of tetrahydrobiopterin?. Med Hypotheses. 2009;73:610–613

PII: S0022-3999(10)00224-2

doi: 10.1016/j.jpsychores.2010.05.007

Journal of Psychosomatic Research
Volume 69, Issue 3 , Pages 327-328 , September 2010

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