Journal of Psychosomatic Research
Volume 69, Issue 5 , Pages 485-490 , November 2010

A randomized controlled trial of quetiapine versus placebo in the treatment of delirium

  • Tayyeb A. Tahir

      Affiliations

    • Department of Liaison Psychiatry, University Hospital of Wales, Cardiff and Vale University Health Board, Heath Park, Cardiff, UK
    • Corresponding Author InformationCorresponding author. Department of Liaison Psychiatry, Room 124, 1st Floor, Monmouth House, University Hospital of Wales, CF14 4XN Cardiff, UK.
    • ,
  • Eamonn Eeles

      Affiliations

    • Department of Geriatric Medicine, School of Medicine, Cardiff University, University Hospital Llandough, Penlan Road, Penarth, UK
    • ,
  • Venugopal Karapareddy

      Affiliations

    • Mersey Care NHS trust, Liverpool, UK
    • ,
  • Prem Muthuvelu

      Affiliations

    • Betsi Cadwaladr University Local Health Board, Rhyl, UK
    • ,
  • Sian Chapple

      Affiliations

    • Chartered Clinical Psychologist, Dorset Healthcare NHS Foundation Trust, Bournemouth, UK
    • ,
  • Bethan Phillips

      Affiliations

    • Inherited Metabolic Disease Service, Children's Centre, Cardiff and Vale University Health Board, Cardiff, UK
    • ,
  • Toyin Adyemo

      Affiliations

    • Hywel Dda Local Health Board, Carmarthenshire, UK
    • ,
  • Daniel Farewell

      Affiliations

    • Department of Primary Care and Public Health, School of Medicine, Cardiff University, Cardiff, UK
    • ,
  • Jonathan I. Bisson

      Affiliations

    • Cardiff University School of Medicine & Cardiff and Vale University Health Board, University Hospital of Wales, Heath Park, Cardiff, UK

Received 21 July 2008 ,Revised 25 March 2010 ,Accepted 11 May 2010.

References 

  1. Siddiqi N, House AO, Holmes JD. Occurrence and outcome of delirium in medical in-patients: a systematic literature review. Age Ageing. 2006;35:350–364
  2. Cole MG. Delirium in elderly patients. Am J Geriatr Psychiatry. 2004;12:7–21
  3. American Psychiatric Association . Practice guidelines for the treatment of patients with delirium. Am J Psychiatry. 1999;156(Suppl):1–20
  4. Sipahimalani A, Masand PS. Olanzapine in the treatment of delirium. Psychosomatics. 1998;39:422–430
  5. Hu H, Deng W, Yong H, Yu Y. Olanzapine and haloperidol for senile delirium: a randomized controlled observation. Chinese Journal of Clinical Rehabilitation. 2006;42:188–190
  6. Skrobik YK, Bergeron N, Dumont M, Gottfried SB. Olanzapine vs haloperidol: treating delirium in a critical care setting. Intensive Care Med. 2004;30:444–449
  7. Kim KY, Bader GM, Kotlyar V, Gropper D. Treatment of delirium in older adults with quetiapine. J Geriatr Psychiatry Neurol. 2003;16:29–31
  8. Lee KU, Won WY, Lee HK, Kweon YS, Lee CT, Pae CU, et al. Amisulpride versus quetiapine for the treatment of delirium: a randomized, open prospective study. Int Clin Psychopharmacol. 2005;20:311–314
  9. Maneeton B, Maneeton N. An open-label study of quetiapine for delirium. J Med Assoc Thai. 2007;90:2158–2163
  10. Kalisvaart KJ, de Jonghe JF, Bogaards MJ, Vreeswijk R, Egberts TC, Burger BJ, et al. Haloperidol prophylaxis for elderly hip surgery patients at risk for delirium: a randomized, placebo-controlled study. J Am Geriatr Soc. 2005;53:1658–1666
  11. Sampson EL, Raven PR, Ndhlovu PN, Vallance A, Garlick N, Watts J, et al. A randomised, double-blind, placebo-controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement. Int J Geriatr Psychiatry. 2006;22:343–349e-pub Sept
  12. Trzepacz PT, Mittal D, Torres R, Kanary K, Norton J, Jimerson N. Validation of the Delirium Rating Scale-Revised-98: comparison with the delirium rating scale and the cognitive test for delirium. J Neuropsychiatry Clin Neurosci. 2001;13:229–242
  13. Trzepacz PT, Bourne R, Zhang S. Designing clinical trials for the treatment of delirium. J Psychosom Res. 2008;65:299–307
  14. Boettger S, Breitbart W. Atypical antipsychotics in the management of delirium: a review of the empirical literature. Palliat Support Care. 2005;3:227–238
  15. Lacasse H, Perreault MM, Williamson DR. Systematic review of antipsychotics for the treatment of hospital-associated delirium in medically or surgically ill patients. Ann Pharmacother. 2006;40:1966–1973
  16. Seitz DP, Gill SS, van Zyl LT. Antipsychotics in the treatment of delirium: a systematic review. J Clin Psychiatry. 2007;68:11–21

☆ Declaration of interest: This is an investigator initiated study. In terms of the Clinical Trials Directive, AstraZeneca UK has legally sponsored and provided funding for recruitment of a research assistant and trial medication.

PII: S0022-3999(10)00223-0

doi: 10.1016/j.jpsychores.2010.05.006

Journal of Psychosomatic Research
Volume 69, Issue 5 , Pages 485-490 , November 2010

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