Journal of Psychosomatic Research
Volume 68, Issue 5 , Pages 469-474 , May 2010

Genetic variation in neuroendocrine genes associates with somatic symptoms in the general population: Results from the EPIFUND study

  • Kate L. Holliday

      Affiliations

    • arc Epidemiology Unit, University of Manchester, Manchester, UK
    • Corresponding Author InformationCorresponding author. arc Epidemiology Unit, University of Manchester, Stopford Building, Oxford Road, M13 9PT Manchester, UK. Tel.: +44 0161 2751674; fax: +44 0161 2755043.
    • nee Limer.
    • ,
  • Gary J. Macfarlane

      Affiliations

    • Aberdeen Pain Research Collaboration (Epidemiology Group), University of Aberdeen, UK
    • ,
  • Barbara I. Nicholl

      Affiliations

    • arc Epidemiology Unit, University of Manchester, Manchester, UK
    • ,
  • Francis Creed

      Affiliations

    • Psychiatry Research Group, School of Medicine, University of Manchester, Manchester, UK
    • ,
  • Wendy Thomson

      Affiliations

    • arc Epidemiology Unit, University of Manchester, Manchester, UK
    • Authors contributed equally.
    • ,
  • John McBeth

      Affiliations

    • arc Epidemiology Unit, University of Manchester, Manchester, UK
    • Authors contributed equally.

Received 16 November 2009 ,Revised 26 January 2010 ,Accepted 28 January 2010.

References 

  1. Wessely S, Nimnuan C, Sharpe M. Functional somatic syndromes: one or many?. Lancet. 1999;354:936–939
  2. Pellegrino MJ, Waylonis GW, Sommer A. Familial occurrence of primary fibromyalgia. Arch Phys Med Rehabil. 1989;70:61–63
  3. Buskila D, Neumann L, Hazanov I, Carmi R. Familial aggregation in fibromyalgia syndrome. Semin Arthritis Rheum. 1996;26:605–611
  4. Arnold LM, Hudson JI, Hess EV, Ware AE, Fritz DA, Auchenbach MB, et al. Family study of fibromyalgia. Arthritis Rheum. 2004;50:944–952
  5. Kato K, Sullivan PF, Evengard B, Pedersen NL. Importance of genetic influences on chronic widespread pain. Arthritis Rheum. 2006;54:1682–1686
  6. Hickie IB, Bansal AS, Kirk KM, Lloyd AR, Martin NG. A twin study of the etiology of prolonged fatigue and immune activation. Twin Res. 2001;4:94–102
  7. Buchwald D, Herrell R, Ashton S, Belcourt M, Schmaling K, Sullivan P, et al. A twin study of chronic fatigue. Psychosom Med. 2001;63:936–943
  8. Morris-Yates A, Talley NJ, Boyce PM, Nandurkar S, Andrews G. Evidence of a genetic contribution to functional bowel disorder. Am J Gastroenterol. 1998;93:1311–1317
  9. Bengtson MB, Ronning T, Vatn MH, Harris JR. Irritable bowel syndrome in twins: genes and environment. Gut. 2006;55:1754–1759
  10. Mohammed I, Cherkas LF, Riley SA, Spector TD, Trudgill NJ. Genetic influences in irritable bowel syndrome: a twin study. Am J Gastroenterol. 2005;100:1340–1344
  11. Levy RL, Jones KR, Whitehead WE, Feld SI, Talley NJ, Corey LA. Irritable bowel syndrome in twins: heredity and social learning both contribute to etiology. Gastroenterology. 2001;121:799–804
  12. Lembo A, Zaman M, Jones M, Talley NJ. Influence of genetics on irritable bowel syndrome, gastro-oesophageal reflux and dyspepsia: a twin study. Aliment Pharmacol Ther. 2007;25:1343–1350
  13. Lembo AJ, Zaman M, Krueger RF, Tomenson BM, Creed FH. Psychiatric disorder, irritable bowel syndrome, and extra-intestinal symptoms in a population-based sample of twins. Am J Gastroenterol. 2009;104:686–694
  14. Kato K, Sullivan PF, Evengard B, Pedersen NL. A population-based twin study of functional somatic syndromes. Psychol Med. 2008;1-9:
  15. Aggarwal VR, McBeth J, Zakrzewska JM, Lunt M, Macfarlane GJ. The epidemiology of chronic syndromes that are frequently unexplained: do they have common associated factors?. Int J Epidemiol. 2006;35:468–476
  16. Nicholl BI, Halder SL, Macfarlane GJ, Thompson DG, O'Brien S, Musleh M, et al. Psychosocial risk markers for new onset irritable bowel syndrome–results of a large prospective population-based study. Pain. 2008;137:147–155
  17. Gupta A, Silman AJ, Ray D, Morriss R, Dickens C, Macfarlane GJ, et al. The role of psychosocial factors in predicting the onset of chronic widespread pain: results from a prospective population-based study. Rheumatology (Oxford). 2007;46:666–671
  18. Gillespie NA, Zhu G, Heath AC, Hickie IB, Martin NG. The genetic aetiology of somatic distress. Psychol Med. 2000;30:1051–1061
  19. Crofford LJ, Pillemer SR, Kalogeras KT. Hypothalamic-pituitary-adrenal axis pertubations in patients with fibromyalgia. Arthritis Rheum. 1994;37:1583–1592
  20. McBeth J, Silman AJ, Gupta A, Chiu YH, Ray D, Morriss R, et al. Moderation of psychosocial risk factors through dysfunction of the hypothalamic-pituitary-adrenal stress axis in the onset of chronic widespread musculoskeletal pain: findings of a population-based prospective cohort study. Arthritis Rheum. 2007;56:360–371
  21. Russell IJ, Vipraio GA, Lopez YG. Serum serotonin in fibromyalgia syndrome, rheumatoid arthritis and healthy normal controls. Arthritis Rheum. 1993;36:S222
  22. Wolfe F, Russell IJ, Vipraio G, Ross K, Anderson J. Serotonin levels, pain threshold, and fibromyalgia symptoms in the general population. J Rheumatol. 1997;24:555–559
  23. Nicholl BI, Limer KL, Macfarlane GJ, Thomson W, Davies KA, McBeth J. Genetic Variation in the Serotonin Pathway Is Associated with Chronic Widespread Pain: Results from the Epifund Study. Rheumatology (Oxford). 2009;48:I14
  24. Holliday KL, Nicholl BI, Macfarlane GJ, Thomson W, Davies KA, McBeth J. Genetic variation in the hypothalamic-pituitary-adrenal stress axis influences susceptibility to musculoskeletal pain: Results from the EPIFUND study. Ann Rheum Dis. 2009;Published Online First: 31 August 2009
  25. Tak LM, Rosmalen JG. Psychoneuroendocrinology of functional somatic disorders. In:  Czerbska MT editors. Psychoneuroendocrinology Research Trends. Nova Science Publishers, Inc.; 2007;p. 463–495
  26. O'Malley PG, Jackson JL, Santoro J, Tomkins G, Balden E, Kroenke K. Antidepressant therapy for unexplained symptoms and symptom syndromes. J Fam Pract. 1999;48:980–990
  27. Creed F. How do SSRIs help patients with irritable bowel syndrome?. Gut. 2006;55:1065–1067
  28. Othmer E, DeSouza C. A screening test for somatization disorder (hysteria). Am J Psychiatry. 1985;142:1146–1149
  29. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67:361–370
  30. Hunt IM, Silman AJ, Benjamin S, McBeth J, Macfarlane GJ. The prevalence and associated features of chronic widespread pain in the community using the ‘Manchester’ definition of chronic widespread pain. Rheumatology (Oxford). 1999;38:275–279
  31. de Bakker PI, Yelensky R, Pe'er I, Gabriel SB, Daly MJ, Altshuler D. Efficiency and power in genetic association studies. Nat Genet. 2005;37:1217–1223
  32. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21:263–265
  33. Gursoy S, Erdal E, Herken H, Madenci E, Alasehirli B. Association of T102C polymorphism of the 5-HT2A receptor gene with psychiatric status in fibromyalgia syndrome. Rheumatol Int. 2001;21:58–61
  34. Bondy B, Spaeth M, Offenbaecher M, Glatzeder K, Stratz T, Schwarz M, et al. The T102C polymorphism of the 5-HT2A-receptor gene in fibromyalgia. Neurobiol Dis. 1999;6:433–439
  35. Smith AK, Dimulescu I, Falkenberg VR, Narasimhan S, Heim C, Vernon SD, et al. Genetic evaluation of the serotonergic system in chronic fatigue syndrome. Psychoneuroendocrinology. 2008;33:188–197
  36. Mutlu N, Erdal ME, Herken H, Oz G, Bayazit YA. T102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction. Oral Dis. 2004;10:349–352
  37. Tander B, Gunes S, Boke O, Alayli G, Kara N, Bagci H, et al. Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. Rheumatol Int. 2008;28:685–691
  38. McBeth J, Macfarlane GJ, Benjamin S, Silman AJ. Features of somatization predict the onset of chronic widespread pain: results of a large population-based study. Arthritis Rheum. 2001;44:940–946
  39. Kroenke K, Spitzer RL, Williams JB. The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms. Psychosom Med. 2002;64:258–266
  40. Barsky AJ, Orav EJ, Bates DW. Somatization increases medical utilization and costs independent of psychiatric and medical comorbidity. Arch Gen Psychiatry. 2005;62:903–910
  41. Li J, Ji L. Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity. 2005;95:221–227
  42. Creed F, Barsky A. A systematic review of the epidemiology of somatisation disorder and hypochondriasis. J Psychosom Res. 2004;56:391–408

PII: S0022-3999(10)00065-6

doi: 10.1016/j.jpsychores.2010.01.024

Journal of Psychosomatic Research
Volume 68, Issue 5 , Pages 469-474 , May 2010

Article Tools

* Image Usage & Resolution