Journal of Psychosomatic Research
Volume 69, Issue 1 , Pages 33-41 , July 2010

Fatigue in patients with diabetes: A review

  • Cynthia Fritschi

      Affiliations

    • Corresponding Author InformationCorresponding author. College of Nursing (MC 802), University of Illinois at Chicago, 845 South Damen Avenue, Chicago, IL 60612, USA. Tel.: +1 312 996 4260.
  • ,
  • Laurie Quinn

Received 11 August 2009 ,Revised 4 January 2010 ,Accepted 22 January 2010.

References 

  1. International Diabetes Federation . Diabetes atlas, third edition. Available at: http://www.eatlas.idf.org/[Accessed 08/05/2009]
  2. American Diabetes Association . Economic costs of diabetes in the U.S. in 2007. Diabetes Care. 2008;31:596–615
  3. Bartley SH. What do we call fatigue. In:  Simonson E,  Weiser PC editor. Psychological and Physiological Aspects of Work and Fatigue. Springfield (Ill): Charles C. Thomas; 1976;p. 409–414
  4. Winningham ML, Nail LM, Burke MB, Brophy L, Cimprich B, Jones LS, et al. Fatigue and the cancer experience: the state of the knowledge. Oncol Nurs Forum. 1994;21:23–36
  5. Wessely S. The epidemiology of chronic fatigue syndrome. Epidemiol Psichiatr Soc. 1998;7:10–24
  6. Aistars J. Fatigue in the cancer patient: a conceptual approach to a clinical problem. Oncol Nurs Forum. 1987;14:25–30
  7. Ream E, Richardson A. Fatigue: a concept analysis. Int J Nurs Stud. 1996;33:519–529
  8. NANDA . Nursing Diagnoses: Definitions and Classification 2001–2002. Philadelphia: North American Nursing Diagnosis Association; 2001;
  9. Aaronson LS, Teel CS, Cassmeyer V, Neuberger GB, Pallikkathayil L, Pierce J, et al. Defining and measuring fatigue. Image J Nurs Scholarsh. 1999;31:45–50
  10. Hart LK, Freel MI. Fatigue. In:  Norris CM editors. Concept Clarification in Nursing. Rockville (Md): Aspen Systems Corporation; 1982;
  11. Lewis G, Wessely S. The epidemiology of fatigue: more questions than answers. J Epidemiol Community Health. 1992;46:92–97
  12. Rose L, Pugh LC, Lears K, Gordon DL. The fatigue experience: persons with HIV infection. J Adv Nurs. 1998;28:295–304
  13. Trendall J. Concept analysis: chronic fatigue. J Adv Nurs. 2000;32:1126–1131
  14. Magnusson K, Moller A, Ekman T, Wallgren A. A qualitative study to explore the experience of fatigue in cancer patients. Eur J Cancer Care (Engl). 1999;8:224–232
  15. Mosso A. Fatigue. London: Swan Sonnenschein & Company; 1904;
  16. Kant IJ, Bultmann U, Schroer KA, Beurskens AJ, Van Amelsvoort LG, Swaen GM. An epidemiological approach to study fatigue in the working population: the Maastricht Cohort Study. Occup Environ Med. 2003;60(Suppl 1):i32–i39
  17. Ream E, Richardson A. Fatigue in patients with cancer and chronic obstructive airways disease: a phenomenological enquiry. Int J Nurs Stud. 1997;34:44–53
  18. LeMone P. The physical effects of diabetes on sexuality in women. Diabetes Educ. 1996;22:361–366
  19. McArdle WD, Katch FI, Katch VL. Neural control of human movement. In:  McArdle WD editors. Exercise Physiology. Philadelphia: Lippincott, Williams and Wilkins; 2001;
  20. Chaudhuri A, Behan PO. Fatigue and basal ganglia. J Neurol Sci. 2000;179(S1–2):34–42
  21. Wijeratne C, Hickie I, Brodaty H. The characteristics of fatigue in an older primary care sample. J Psychosom Res. 2007;62:153–158
  22. Drayer RA, Mulsant BH, Lenze EJ, Rollman BL, Dew MA, Kelleher K, et al. Somatic symptoms of depression in elderly patients with medical comorbidities. Int J Geriatr Psychiatry. 2005;20:973–982
  23. Sugahara H, Akamine M, Kondo T, Fujisawa K, Yoshimasu K, Tokunaga S, et al. Somatic symptoms most often associated with depression in an urban hospital medical setting in Japan. Psychiatry Res. 2004;128:305–311
  24. Lavidor M, Weller A, Babkoff H. Multidimensional fatigue, somatic symptoms and depression. Br J Health Psychol. 2002;7(Pt 1):67–75
  25. Vaccarino AL, Sills TL, Evans KR, Kalali AH. Prevalence and association of somatic symptoms in patients with major depressive disorder. J Affect Disord. 2008;
  26. Kroenke K, Price RK. Symptoms in the community. Prevalence, classification, and psychiatric comorbidity. Arch Intern Med. 1993;153:2474–2480
  27. American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Washington, DC: American Psychiatric Association; 1994;
  28. Zimmerman M, McGlinchey JB, Young D, Chelminski I. Diagnosing major depressive disorder III: Can some symptoms be eliminated from the diagnostic criteria?. J Nerv Ment Dis. 2006;194:313–317
  29. Stewart ST, Woodward RM, Rosen AB, Cutler DM. The impact of symptoms and impairments on overall health in US national health data. Med Care. 2008;46:954–962
  30. Avlund K, Mehlsen MY, Thomsen DK, Viidik A, Zachariae R. Physical functioning and use of health services in a young and old sample. The influence of fatigue. Dan Med Bull. 2008;55:147–151
  31. Nijrolder I, van der Windt DA, van der Horst HE. Prognosis of fatigue and functioning in primary care: a 1-year follow-up study. Ann Fam Med. 2008;6:519–527
  32. Morsch CM, Goncalves LF, Barros E. Health-related quality of life among haemodialysis patients—relationship with clinical indicators, morbidity and mortality. J Clin Nurs. 2006;15:498–504
  33. Weijman I, Kant I, Swaen GM, Ros WJ, Rutten GE, Schaufeli WB, et al. Diabetes, employment and fatigue-related complaints: a comparison between diabetic employees, “healthy” employees, and employees with other chronic diseases. J Occup Environ Med. 2004;46:828–836
  34. Rijken PM, Dekker J, Dekker E, Lankhorst GJ, Bakker K, Dooren J, et al. Clinical and functional correlates of foot pain in diabetic patients. Disabil Rehabil. 1998;20:330–336
  35. Warren RE, Deary IJ, Frier BM. The symptoms of hyperglycaemia in people with insulin-treated diabetes: classification using principal components analysis. Diabetes Metab Res. 2003;19:408–414
  36. Sommerfield AJ, Deary IJ, Frier BM. Acute hyperglycemia alters mood state and impairs cognitive performance in people with type 2 diabetes. Diabetes Care. 2004;27:2335–2340
  37. Drivsholm T, de Fine Olivarius N, Nielsen AB, Siersma V. Symptoms, signs and complications in newly diagnosed type 2 diabetic patients, and their relationship to glycaemia, blood pressure and weight. Diabetologia. 2005;
  38. Bulpitt CJ, Palmer AJ, Battersby C, Fletcher AE. Association of symptoms of type 2 diabetic patients with severity of disease, obesity, and blood pressure. Diabetes Care. 1998;21:111–115
  39. King P, Kong MF, Parkin H, Macdonald IA, Tattersall RB. Well-being, cerebral function, and physical fatigue after nocturnal hypoglycemia in IDDM. Diabetes Care. 1998;21:341–345
  40. Van der Does FE, De Neeling JN, Snoek FJ, Kostense PJ, Grootenhuis PA, Bouter LM, et al. Symptoms and well-being in relation to glycemic control in type II diabetes. Diabetes Care. 1996;19:204–210
  41. Grootenhuis PA, Snoek FJ, Heine RJ, Bouter LM. Development of a type 2 diabetes symptom checklist: a measure of symptom severity. Diabet Med. 1994;11:253–261
  42. McNair D, Heuchert JW. Profile of Mood States: Technical Update. Toronto (Canada): Multi-Health Systems, Inc.; 2003;
  43. de Sonnaville JJ, Snoek FJ, Colly LP, Deville W, Wijkel D, Heine RJ. Well-being and symptoms in relation to insulin therapy in type 2 diabetes. Diabetes Care. 1998;21:919–924
  44. Cuellar NG, Ratcliffe SJ. A comparison of glycemic control, sleep, fatigue, and depression in type 2 diabetes with and without restless legs syndrome. J Clin Sleep Med. 2008;4:50–56
  45. Kovatchev BP, Cox DJ, Gonder-Frederick L, Clarke WL. Methods for quantifying self-monitoring blood glucose profiles exemplified by an examination of blood glucose patterns in patients with type 1 and type 2 diabetes. Diabetes Technol Ther. 2002;4:295–303
  46. Bonora E, Calcaterra F, Lombardi S, Bonfante N, Formentini G, Bonadonna RC, et al. Plasma glucose levels throughout the day and HbA(1c) interrelationships in type 2 diabetes: Implications for treatment and monitoring of metabolic control. Diabetes Care. 2001;24:2023–2029
  47. Bonora E, Muggeo M. Postprandial blood glucose as a risk factor for cardiovascular disease in type II diabetes: The epidemiological evidence. Diabetologia. 2001;44(12):2107–2114
  48. Praet SF, Manders RJ, Meex RC, Lieverse AG, Stehouwer CD, Kuipers H, et al. Glycaemic instability is an underestimated problem in type II diabetes. Clin Sci (Lond). 2006;111:119–126
  49. Monnier L, Mas E, Ginet C, Michel F, Villon L, Cristiol JP, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA. 2006;295:1681–1687
  50. Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ. Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Biol Med. 2005;39:584–589
  51. American Diabetes Association. Diabetes statistics. www.diabetes.org/diabetes-statistics/national-diabetes-fact-sheet.jsp. [Accessed 8/9/2009].
  52. Deray G, Heurtier A, Grimaldi A, Launay Vacher V, Isnard Bagnis C. Anemia and diabetes. Am J Nephrol. 2004;24:522–526
  53. Thomas MC, MacIsaac RJ, Tsalamandris C, Power D, Jerums G. Unrecognized anemia in patients with diabetes: a cross-sectional survey. Diabetes Care. 2003;26:1164–1169
  54. Weijman I, Ros WJ, Rutten GE, Schaufeli WB, Schabracq MJ, Winnubst JA. Fatigue in employees with diabetes: its relation with work characteristics and diabetes related burden. Occup Environ Med. 2003;60(Suppl 1):i93–i98
  55. Rubin RR. Dealing with “diabetes overwhelmus”. Available at http://www.diabetesselfmanagement.com[Accessed 9/10/2008]
  56. Polonsky WH, Anderson BJ, Lohrer PA, Welch G, Jacobson AM, Aponte JE, et al. Assessment of diabetes-related distress. Diabetes Care. 1995;18:754–760
  57. Polonsky WH. Emotional and quality-of-life aspects of diabetes management. Curr Diab Rep. 2002;2:153–159
  58. Polonsky WH. Diabetes Burnout: What to do When You Can't Take it Anymore. Alexandria (Va): American Diabetes Association; 1999;
  59. Polonsky WH, Fisher L, Earles J, Dudl RJ, Lees J, Mullan J, et al. Assessing psychosocial distress in diabetes: development of the diabetes distress scale. Diabetes Care. 2005;28:626–631
  60. Casalenuovo GA. In: University of Tennessee  editors. Fatigue in Diabetes Mellitus: Testing a Middle Range Theory of Well-Being Derived From Neuman's Theory of Optimal Client System Stability and the Neuman Systems Model. Knoxville (Tenn): University of Tennessee; 2002;
  61. Maslach C, Schaufeli WB, Leiter MP. Job burnout. Annu Rev Psychol. 2001;52:397–422
  62. Von Korff M, Katon W, Lin EH, Simon G, Ciechanowski P, Ludman E, et al. Work disability among individuals with diabetes. Diabetes Care. 2005;28:1326–1332
  63. Anderson RJ, Freedland KE, Clouse RE, Lustman PJ. The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care. 2001;24:1069–1078
  64. Golden SH, Lazo M, Carnethon M, Bertoni AG, Schreiner PJ, Roux AV, et al. Examining a bidirectional association between depressive symptoms and diabetes. JAMA. 2008;299:2751–2759
  65. de Jonge P, Roy JF, Saz P, Marcos G, Lobo A, ZARADEMP Investigators . Prevalent and incident depression in community-dwelling elderly persons with diabetes mellitus: results from the ZARADEMP project. Diabetologia. 2006;49:2627–2633
  66. Golden SH, Williams JE, Ford DE, Yeh HC, Paton Sanford C, Nieto FJ, et al. Depressive symptoms and the risk of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes Care. 2004;27:429–435
  67. Palinkas LA, Lee PP, Barrett-Connor E. A prospective study of type 2 diabetes and depressive symptoms in the elderly: the Rancho Bernardo Study. Diabet Med. 2004;21:1185–1191
  68. American Diabetes Association . Diagnosis and classification of diabetes mellitus. Diabetes Care. 2008;31(Suppl 1):S55–S60
  69. Resnick HE, Carter EA, Aloia M, Phillips B. Cross-sectional relationship of reported fatigue to obesity, diet, and physical activity: results from the third national health and nutritional examination survey. JCSM. 2006;2:163–169
  70. Theorell-Haglow J, Lindberg E, Janson C. What are the important risk factors for daytime sleepiness and fatigue in women?. Sleep. 2006;29:751–757
  71. Lim W, Hong S, Nelesen R, Dimsdale JE. The association of obesity, cytokine levels, and depressive symptoms with diverse measures of fatigue in healthy subjects. Arch Intern Med. 2005;165:910–915
  72. Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care. 2004;27:813–823
  73. Miller MA, Cappuccio FP. Inflammation, sleep, obesity and cardiovascular disease. Curr Vasc Pharmacol. 2007;5:93–102
  74. Vgontzas AN, Bixler EO, Chrousos GP. Obesity-related sleepiness and fatigue: the role of the stress system and cytokines. Ann N Y Acad Sci. 2006;1083:329–344
  75. Puetz TW. Physical activity and feelings of energy and fatigue: epidemiological evidence. Sports Med. 2006;36:767–780
  76. Puetz TW, Beasman KM, O'Connor PJ. The effect of cardiac rehabilitation exercise programs on feelings of energy and fatigue: a meta-analysis of research from 1945 to 2005. Eur J Cardiovasc Prev Rehabil. 2006;13:886–893
  77. Puetz TW, O'Connor PJ, Dishman RK. Effects of chronic exercise on feelings of energy and fatigue: a quantitative synthesis. Psychol Bull. 2006;132:866–876
  78. O'Connor PJ, Puetz TW. Chronic physical activity and feelings of energy and fatigue. Med Sci Sports Exerc. 2005;37:299–305
  79. Mock V, Frangakis C, Davidson NE, Ropka ME, Pickett M, Poniatowski B, et al. Exercise manages fatigue during breast cancer treatment: a randomized controlled trial. Psychooncology. 2004;
  80. Neuberger GB, Press AN, Lindsley HB, Hinton R, Cagle PE, Carlson K, et al. Effects of exercise on fatigue, aerobic fitness, and disease activity measures in persons with rheumatoid arthritis. Res Nurs Health. 1997;195–204
  81. Stewart AL, Hays RD, Wells KB, Rogers WH, Spritzer KL, Greenfield S. Long-term functioning and well-being outcomes associated with physical activity and exercise in patients with chronic conditions in the medical outcomes study. J Clin Epidemiol. 1994;47:719–730
  82. Glass JM, Lyden AK, Petzke F, Stein P, Whalen G, Ambrose K, et al. The effect of brief exercise cessation on pain, fatigue, and mood symptom development in healthy, fit individuals. J Psychosom Res. 2004;57:391–398
  83. Morrato EH, Hill JO, Wyatt HR, Ghushchyan V, Sullivan PW. Physical activity in U.S. adults with diabetes and at risk for developing diabetes, 2003. Diabetes Care. 2007;30:203–209
  84. Lim K, Taylor L. Factors associated with physical activity among older people—a population-based study. Prev Med. 2005;40:33–40
  85. Hays LM, Clark DO. Correlates of physical activity in a sample of older adults with type 2 diabetes. Diabetes Care. 1999;22:706–712
  86. Wood FG. Leisure time activity of Mexican Americans with diabetes. J Adv Nurs. 2004;45:190–196
  87. Ford ES, Herman WH. Leisure-time physical activity patterns in the U.S. diabetic population. findings from the 1990 National Health Interview Survey—health promotion and disease prevention supplement. Diabetes Care. 1995;18:27–33
  88. Stover JC, Skelly AH, Holditch-Davis D, Dunn PF. Perceptions of health and their relationship to symptoms in African American women with type 2 diabetes. Appl Nurs Res. 2001;14:72–80
  89. Varni JW, Limbers CA, Bryant WP, Wilson DP. The PedsQL multidimensional fatigue scale in type 1 diabetes: feasibility, reliability, and validity. Pediatr Diabetes. 2008;
  90. Hill-Briggs F, Cooper DC, Loman K, Brancati FL, Cooper LA. A qualitative study of problem solving and diabetes control in type 2 diabetes self-management. Diabetes Educ. 2003;29:1018–1028
  91. Koch T, Kralik D, Sonnack D. Women living with type II diabetes: the intrusion of illness. J Clin Nurs. 1999;8:712–722
  92. Samuel-Hodge CD, Headen SW, Skelly AH, Ingram AF, Keyserling TC, Jackson EJ, et al. Influences on day-to-day self-management of type 2 diabetes among African-American women: spirituality, the multi-caregiver role, and other social context factors. Diabetes Care. 2000;23:928–933
  93. Wenzel J, Utz SW, Steeves R, Hinton I, Jones R. “Plenty of sickness” descriptions by African Americans living in rural areas with type 2 diabetes. Diabetes Educ. 2005;31:98–107
  94. Samuel-Hodge CD, Skelly AH, Headen S, Carter-Edwards L. Familial roles of older African-American women with type 2 diabetes: testing of a new multiple caregiving measure. Ethn Dis. 2005;15:436–443
  95. Chasens ER, Olshansky E. Daytime sleepiness, diabetes, and psychological well-being. Issues Ment Health Nurs. 2008;29:1134–1150
  96. Gandhi GY, Murad MH, Fujiyoshi A, Mullan RJ, Flynn DN, Elamin MB, et al. Patient-important outcomes in registered diabetes trials. JAMA. 2008;299:2543–2549
  97. Skelly AH, Carlson JR, Leeman J, Holditch-Davis D, Soward AC. Symptom-focused management for African American women with type 2 diabetes: a pilot study. Appl Nurs Res. 2005;18:213–220

 This research was funded in part by the National Institutes of Health/National Institute for Nursing Research F31 NR009751.

PII: S0022-3999(10)00062-0

doi: 10.1016/j.jpsychores.2010.01.021

Journal of Psychosomatic Research
Volume 69, Issue 1 , Pages 33-41 , July 2010