Journal of Psychosomatic Research
Volume 68, Issue 5 , Pages 447-453 , May 2010

Latent class analysis of functional somatic symptoms in a population-based sample of twins

  • Kenji Kato

      Affiliations

    • School of Nursing and Rehabilitation, International University of Health and Welfare, Odawara, Japan
    • Department of Health Promotion Science, Graduate School of Medicine, Osaka University, Suita, Japan
    • Department of Medical Epidemiology and Biostatistics, The Karolinska Institute, Stockholm, Sweden
    • Corresponding Author InformationCorresponding author. Department of Health Promotion Science (c/o Prof Kazuo Hayakawa), Graduate School of Medicine, Osaka University, 1-7 Yamada-Oka, Suita 565-0871 Japan.
    • ,
  • Patrick F. Sullivan

      Affiliations

    • Department of Medical Epidemiology and Biostatistics, The Karolinska Institute, Stockholm, Sweden
    • Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    • Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    • Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    • ,
  • Nancy L. Pedersen

      Affiliations

    • Department of Medical Epidemiology and Biostatistics, The Karolinska Institute, Stockholm, Sweden
    • Department of Psychology, University of Southern California, Los Angeles, CA, USA

Received 2 December 2009 ,Revised 12 January 2010 ,Accepted 12 January 2010.

References 

  1. Wessely S, Nimnuan C, Sharpe M. Functional somatic syndromes: one or many?. Lancet. 1999;354:936–939
  2. Henningsen P, Zipfel S, Herzog W. Management of functional somatic syndromes. Lancet. 2007;369:946–955
  3. Kanaan RAA, Lepine JP, Wessely SC. The association or otherwise of the functional somatic syndromes. Psychosom Med. 2007;69:855–859
  4. Aaron LA, Herrell R, Ashton S, Belcourt M, Schmaling K, Goldberg J, et al. Comorbid clinical conditions in chronic fatigue: a co-twin control study. J Gen Intern Med. 2001;16:24–31
  5. Kato K, Sullivan PF, Evengård B, Pedersen NL. A population-based twin study of functional somatic syndromes. Psychol Med. 2009;39:497–505
  6. Fukuda K, Straus SE, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study. International Chronic Fatigue Syndrome Study Group. Ann Intern Med. 1994;121:953–959
  7. Sullivan PF, Smith W, Buchwald D. Latent class analysis of symptoms associated with chronic fatigue syndrome and fibromyalgia. Psychol Med. 2002;32:881–888
  8. Sullivan PF, Kessler RC, Kendler KS. Latent class analysis of lifetime depressive symptoms in the National Comorbidity Survey. Am J Psychiatry. 1998;155:1398–1406
  9. Lichtenstein P, De Faire U, Floderus B, Svartengren M, Svedberg P, Pedersen NL. The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies. J Intern Med. 2002;252:184–205
  10. Lichtenstein P, Sullivan PF, Cnattingius S, Gatz M, Johansson S, Carlstrom E, et al. The Swedish Twin Registry in the third millennium: an update. Twin Res Hum Genet. 2006;9:875–882
  11. Evengård B, Jacks A, Pedersen NL, Sullivan PF. The epidemiology of chronic fatigue in the Swedish Twin Registry. Psychol Med. 2005;35:1317–1326
  12. Kato K, Sullivan PF, Evengård B, Pedersen NL. Importance of genetic influences on chronic widespread pain. Arthritis Rheum. 2006;54:1682–1686
  13. Kato K, Sullivan PF, Evengård B, Pedersen NL. Chronic widespread pain and its comorbidities: a population-based study. Arch Intern Med. 2006;166:1649–1654
  14. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990;33:160–172
  15. Svedberg P, Johansson S, Wallander MA, Hamelin B, Pedersen NL. Extra-intestinal manifestations associated with irritable bowel syndrome: a twin study. Aliment Pharmacol Ther. 2002;16:975–983
  16. Wojczynski MK, North KE, Pedersen NL, Sullivan PF. Irritable bowel syndrome: a co-twin control analysis. Am J Gastroenterol. 2007;102:2220–2229
  17. Cameron AJ, Lagergren J, Henriksson C, Nyren O, Locke GR, Pedersen NL. Gastroesophageal reflux disease in monozygotic and dizygotic twins. Gastroenterology. 2002;122:55–59
  18. Zheng Z, Nordenstedt H, Pedersen NL, Lagergren J, Ye W. Lifestyle factors and risk for symptomatic gastroesophageal reflux in monozygotic twins. Gastroenterology. 2007;132:87–95
  19. Svensson DA, Larsson B, Waldenlind E, Pedersen NL. Genetic and environmental influences on expression of recurrent headache as a function of the reporting age in twins. Twin Res. 2002;5:277–286
  20. Kessler RC, Andrews G, Mroczek CK, Ustun B, Wittchen H-U. The World Health Organization Composite International Diagnostic Interview Short Form (CIDI-SF). Int J Methods Psychiatr Res. 1998;7:171–185
  21. Kendler KS, Gatz M, Gardner CO, Pedersen NL. A Swedish national twin study of lifetime major depression. Am J Psychiatry. 2006;163:109–114
  22. Mackintosh MA, Gatz M, Wetherell JL, Pedersen NL. A twin study of lifetime generalized anxiety disorder (GAD) in older adults: genetic and environmental influences shared by neuroticism and GAD. Twin Res Hum Genet. 2006;9:30–37
  23. Neale MC, Boker SM, Xie G, Maes HHM. Mx: Statistical Modeling. Richmond (Va): Virginia Commonwealth University Department of Psychiatry; 2004;
  24. Watanabe N, Stewart R, Jenkins R, Bhugra DK, Furukawa TA. The epidemiology of chronic fatigue, physical illness, and symptoms of common mental disorders: a cross-sectional survey from the second British National Survey of Psychiatric Morbidity. J Psychosom Res. 2008;64:357–362
  25. Aggarwal VR, McBeth J, Zakrzewska JM, Lunt M, Macfarlane GJ. The epidemiology of chronic syndromes that are frequently unexplained: do they have common associated factors?. Int J Epidemiol. 2006;35:468–476
  26. Lembo AJ, Zaman M, Krueger RF, Tomenson BM, Creed FH. Psychiatric disorder, irritable bowel syndrome, and extra-intestinal symptoms in a population-based sample of twins. Am J Gastroenterol. 2009;104:686–694
  27. Schondorf R, Freeman R. The importance of orthostatic intolerance in the chronic fatigue syndrome. Am J Med Sci. 1999;317:117–123
  28. Henningsen P, Herzog W. Irritable bowel syndrome and somatoform disorders. J Psychosom Res. 2008;64:625–629
  29. Sullivan PF, Pedersen NL, Jacks A, Evengård B. Chronic fatigue in a population sample: definitions and heterogeneity. Psychol Med. 2005;35:1337–1348
  30. Sullivan PF, Evengård B, Jacks A, Pedersen NL. Twin analyses of chronic fatigue in a Swedish national sample. Psychol Med. 2005;35:1327–1336
  31. Gillespie NA, Zhu G, Heath AC, Hickie IB, Martin NG. The genetic aetiology of somatic distress. Psychol Med. 2000;30:1051–1061
  32. Kendler KS, Walters EE, Truett KR, Heath AC, Neale MC, Martin NG, et al. A twin-family study of self-report symptoms of panic-phobia and somatization. Behav Genet. 1995;25:499–515
  33. Wessely S, White PD. There is only one functional somatic syndrome. Br J Psychiatry. 2004;185:95–96

☆ This work was supported by NS-041483 (NLP), CA-085739 (PFS), and AI-056014 (PFS). The Swedish Twin Registry is supported by grants from the Swedish Department of Higher Education, the Swedish Scientific Council, and an unrestricted grant from AstraZeneca.

PII: S0022-3999(10)00015-2

doi: 10.1016/j.jpsychores.2010.01.010

Journal of Psychosomatic Research
Volume 68, Issue 5 , Pages 447-453 , May 2010

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