Journal of Psychosomatic Research
Volume 68, Issue 5 , Pages 455-459 , May 2010

Chronic fatigue syndrome: Is it one discrete syndrome or many? Implications for the “one vs. many” functional somatic syndromes debate

  • Peter D. White

      Affiliations

    • Corresponding Author InformationDepartment of Psychological Medicine, St Bartholomew's Hospital, London, EC1A 7BE, UK. Tel.: +44 207 601 8108; fax: +44 207 601 7097.

Received 10 November 2009 ,Revised 12 January 2010 ,Accepted 14 January 2010.

References 

  1. Fukuda K, Straus S, Hickie I, Sharpe MC, Dobbins JG, Komaroff A, et al. The chronic fatigue syndrome: a comprehensive approach to its definition and study. Ann Intern Med. 1994;121:953–959
  2. Reeves WC, Lloyd A, Vernon SD, Klimas N, Jason LA, Bleijenberg G, et al. Identification of ambiguities in the 1994 chronic fatigue syndrome research case definition and recommendations for resolution. BMC Health Serv Res. 2003;3:25;http://www.biomedcentral.com/1472-6963/3/25
  3. Sharpe MC, Archard LC, Banatvala JE, Borysiewicz LK, Clare AW, David AS, et al. A report — chronic fatigue syndrome. J R Soc Med. 1991;84:118–121
  4. Reeves WC, Wagner D, Nisenbaum R, Jones JF, Gurbaxani B, Solomon L, et al. Chronic fatigue syndrome — A clinically empirical approach to its definition and study. BMC Medicine. 2005;3:19
  5. Sullivan PF, Pedersen NL, Jacks A, Evengard B. Chronic fatigue in a population sample: definitions and heterogeneity. Psychol Med. 2005;35:1337–1348
  6. Hickie I, Davenport T, Vernon SD, Nisenbaum R, Reeves WC, Hadzi-Pavlovic D, et al. Are chronic fatigue and chronic fatigue syndrome valid clinical entities across countries and health-care settings?. Austral NZ J Psychiatry. 2009;43:25–35
  7. Wessely S, Chalder T, Hirsch S, Wallace P, Wright D. The prevalence and morbidity of chronic fatigue and chronic fatigue syndrome: a prospective primary care study. Am J Public Health. 1997;87:1449–1455
  8. Dinos S, Khoshaba B, Ashby D, White PD, Nazroo J, Wessely S, et al. A systematic review of chronic fatigue, its syndromes and ethnicity: prevalence, severity, co-morbidity and coping. Int J Epidemiol. 2009;38:1554–1570
  9. White PD, Thomas JM, Kangro HO, Bruce-Jones WDA, Amess J, Crawford DH, et al. Predictions and associations of fatigue syndromes and mood disorders that occur after infectious mononucleosis. Lancet. 2001;358:1946–1954
  10. Hickie I, Davenport T, Wakefield D, Vollmer-Conna U, Cameron B, Vernon SD, et al. Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study. BMJ. 2006;333:575–578
  11. Hickie I, Lloyd A, Hadzi-Pavlovic D, Parker G, Bird K, Wakefield A. Can the chronic fatigue syndrome be defined by distinct clinical features?. Psychol Med. 1995;25:925–935
  12. Wilson A, Hickie I, Hadzi-Pavlovic D, Wakefield D, Parker G, Straus SE, et al. What is chronic fatigue syndrome? Heterogeneity within an international multicentre study. Aust NZ J Psychiatry. 2001;35:520–527
  13. Sullivan PF, Smith W, Buchwald D. Latent class analysis of symptoms associated with chronic fatigue syndrome and fibromyalgia. Psychol Med. 2002;32:881–888
  14. Nisenbaum R, Reyes M, Unger ER, Reeves WC. Factor analysis of symptoms among subjects with unexplained chronic fatigue: What can we learn about chronic fatigue syndrome?. J Psychosom Res. 2004;56:171–178
  15. May M, Emond A, Crawley E. Phenotypes of chronic fatigue syndrome in children and young people. Arch Dis Child. 2009;[Epub ahead of print] http://www.fetalneonatal.com/content/early/2009/10/19/adc.2009.158162.abstract
  16. Cleare AJ. The neuroendocrinology of chronic fatigue syndrome. Endocrine Rev. 2003;24:236–252
  17. Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003;160:636–645
  18. Reyes M, Nisenbaum R, Hoaglin DC, Unger ER, Emmons C, Randall B, et al. Prevalence and incidence of chronic fatigue syndrome in Wichita. Kansas. Arch Intern Med. 2003;163:1530–1536
  19. Vollmer-Conna U, Aslakson E, White PD. An empirical delineation of the heterogeneity of chronic unexplained fatigue. Pharmacogenomics. 2006;7:355–364
  20. Aslakson E, Vollmer-Conna U, White PD. The validity of an empirical delineation of heterogeneity in chronic unexplained fatigue. Pharmacogenomics. 2006;7:365–373
  21. Carmel L, Efroni S, White PD, Aslakson E, Vollmer-Conna U, Rajeevan MS. Gene expression profile of empirically delineated classes of unexplained chronic fatigue. Pharmacogenomics. 2006;7:375–386
  22. Smith AK, White PD, Aslakson E, Vollmer-Conna U, Rajeevan MS. Polymorphisms in genes regulating HPA axis associated with empirically delineated classes of unexplained chronic fatigue. Pharmacogenomics. 2006;7:387–394
  23. Aslakson E, Vollmer-Conna U, Reeves WC, White PD. Replication of an empirical approach to delineate the heterogeneity of chronic unexplained fatigue. Pop Health Metrics. 2009;7:17;http://www.pophealthmetrics.com/content/7/1/17
  24. Wilson HD, Starz TW, Robinson JP, Turk DC. Heterogeneity within the fibromyalgia population: theoretical implications of variable tender point severity ratings. J Rheumatol. 2009;36:2795–2801
  25. Guilera M, Balboa A, Mearin F. Bowel habit subtypes and temporal patterns in irritable bowel syndrome: systematic review. Am J Gastroenterol. 2005;100:1174–1184
  26. Riedl A, Schmidtmann M, Stengel A, Goebel M, Wisser A, Klapp B, et al. Somatic comorbidities of irritable bowel syndrome: a systematic analysis. J Psychosom Res. 2008;64:573–582
  27. Aggarwal VR, McBeth J, Zakrzewska JM, Lunt M, Macfarlane GJ. The epidemiology of chronic syndromes that are frequently unexplained: do they have common associated factors?. Int J Epidemiol. 2006;35:468–476
  28. Kato K, Sullivan PF, Evengard B, Pedersen NL. Chronic widespread pain and its comorbidities: a population-based study. Arch Intern Med. 2006;166:1649–1654
  29. Wessely S, Nimnuan C, Sharpe M. Functional somatic syndromes: one or many?. Lancet. 1999;354:936–939
  30. Wessely S, White PD. In debate: there is only one functional somatic syndrome. Br J Psychiatry. 2004;185:95–96
  31. Hamilton WT, Gallagher AM, Thomas JM, White PD. Risk markers for both chronic fatigue and irritable bowel syndromes: a prospective case-control study in primary care. Psychol Med. 2009;39:1913–1921
  32. Moss-Morris R, Spence M. To ‘lump’ or to ‘split’ the functional somatic syndromes: can infectious and emotional risk factors differentiate between the onset of chronic fatigue syndrome and irritable bowel syndrome?. Psychosom Med. 2006;68:463–469
  33. Kato K, Sullivan PF, Evengård B, Pedersen NL. A population-based twin study of functional somatic syndromes. Psychol Med. 2009;39:497–505
  34. Kato K, Sullivan PF, Evengard B, Pedersen NL. Premorbid predictors of chronic fatigue. Arch Gen Psychiatry. 2006;63:1267–1272
  35. Harvey SB, Wadsworth M, Wessely S, Hotopf M. The relationship between prior psychiatric disorder and chronic fatigue: evidence from a national birth cohort study. Psychol Med. 2008;38:933–940
  36. Heim C, Wagner D, Maloney E, Papanicolaou DA, Solomon L, Jones JF, et al. Early adverse experience and risk for chronic fatigue syndrome: results from a population-based study. Arch Gen Psychiatry. 2006;63:1258–1266
  37. Heim C, Nater UM, Maloney E, Boneva R, Jones JF, Reeves WC. Childhood trauma and risk for chronic fatigue syndrome: association with neuroendocrine dysfunction. Arch Gen Psychiatry. 2009;66:72–80
  38. Paras ML, Murad MH, Chen LP, Goranson EN, Sattler AI, Colbenson KL, et al. Sexual abuse and lifetime diagnosis of somatic disorders: a systematic review and meta-analysis. JAMA. 2009;302:550–561
  39. Ablin K, Clauw DJ. From fibrositis to functional somatic syndromes to a bell-shaped curve of pain and sensory sensitivity: evolution of a clinical construct. Rheum Dis Clin N America. 2009;35:233–251
  40. McEwen B. Understanding the potency of stressful early life experiences on brain and body function. Metabolism. 2008;57:S11–S15
  41. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science. 2007;316:889–894
  42. Desautels A, Turecki G, Montplaisir J, Xiong L, Walters AS, Ehrenberg BL, et al. Restless legs syndrome: confirmation of linkage to chromosome 12q, genetic heterogeneity, and evidence of complexity. Arch Neurol. 2005;62:591–596

PII: S0022-3999(10)00013-9

doi: 10.1016/j.jpsychores.2010.01.008

Journal of Psychosomatic Research
Volume 68, Issue 5 , Pages 455-459 , May 2010