Journal of Psychosomatic Research
Volume 68, Issue 2 , Pages 139-147 , February 2010

Alexithymia, hypertension, and subclinical atherosclerosis in the general population

  • Hans Joergen Grabe

      Affiliations

    • Department of Psychiatry and Psychotherapy, University of Greifswald, Greifswald, Germany
    • Corresponding Author InformationCorresponding author. Department of Psychiatry, HANSE-Klinikum Stralsund, University of Greifswald, Rostocker Chaussee 70, 18437 Stralsund, Germany. Tel.: +49 (0) 3831/45 2106; fax: +49 (0) 3831/45 2105.
    • These authors contributed equally to the paper.
    • ,
  • Christian Schwahn

      Affiliations

    • Institute for Community Medicine, University of Greifswald, Greifswald, Germany
    • These authors contributed equally to the paper.
    • ,
  • Sven Barnow

      Affiliations

    • Department of Clinical Psychology, University of Heidelberg, Heidelberg, Germany
    • ,
  • Carsten Spitzer

      Affiliations

    • Department of Psychosomatic Medicine and Psychotherapy, University of Hamburg, Hamburg, Germany
    • ,
  • Ulrich John

      Affiliations

    • Institute of Epidemiology and Social Medicine, University of Greifswald, Greifswald, Germany
    • ,
  • Harald J. Freyberger

      Affiliations

    • Department of Psychiatry and Psychotherapy, University of Greifswald, Greifswald, Germany
    • ,
  • Ulf Schminke

      Affiliations

    • Department of Neurology, University of Greifswald, Greifswald, Germany
    • ,
  • Stephan Felix

      Affiliations

    • Department of Internal Medicine B, University of Greifswald, Greifswald, Germany
    • ,
  • Henry Völzke

      Affiliations

    • Institute for Community Medicine, University of Greifswald, Greifswald, Germany

Received 10 March 2009 ,Revised 13 July 2009 ,Accepted 21 July 2009.

References 

  1. Kawachi I, Sparrow D, Kubzansky LD, Spiro A, Vokonas PS, Weiss ST. Prospective study of a self-report type A scale and risk of coronary heart disease: test of the MMPI-2 type A scale. Circulation. 1998;98:405–412
  2. Kuper H, Marmot M, Hemingway H. Systematic review of prospective cohort studies of psychosocial factors in the etiology and prognosis of coronary heart disease. Semin Vasc Med. 2002;2:267–314
  3. Denollet J, Sys SU, Stroobant N, Rombouts H, Gillebert TC, Brutsaert DL. Personality as independent predictor of long-term mortality in patients with coronary heart disease. Lancet. 1996;347:417–421
  4. Thayer JF, Sternberg E. Beyond heart rate variability: vagal regulation of allostatic systems. Ann N Y Acad Sci. 2006;1088:361–372
  5. Rozanski A, Blumenthal JA, Kaplan J. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation. 1999;99:2192–2217
  6. Schwartz AR, Gerin W, Davidson KW, Pickering TG, Brosschot JF, Thayer JF, et al. Toward a causal model of cardiovascular responses to stress and the development of cardiovascular disease. Psychosom Med. 2003;65:22–35
  7. Thayer JF, Lane RD. The role of vagal function in the risk for cardiovascular disease and mortality. Biol Psychol. 2007;74:224–242
  8. Bagby RM, Parker JD, Taylor GJ. The twenty-item Toronto Alexithymia Scale—I. Item selection and cross-validation of the factor structure. J Psychosom Res. 1994;38:23–32
  9. Bagby RM, Taylor GJ, Parker JD. The twenty-item Toronto Alexithymia Scale—II. Convergent, discriminant, and concurrent validity. J Psychosom Res. 1994;38:33–40
  10. Grabe HJ, Spitzer C, Freyberger HJ. Alexithymia and personality in relation to dimensions of psychopathology. Am J Psychiatry. 2004;161:1299–1301
  11. Lumley MA, Neely LC, Burger AJ. The assessment of alexithymia in medical settings: implications for understanding and treating health problems. J Pers Assess. 2007;89:230–246
  12. Taylor GJ, Bagby RM. New trends in alexithymia research. Psychother Psychosom. 2004;73:68–77
  13. Taylor GJ, Bagby RM, Parker JDA. Disorders of affect regulation: alexithymia in medical and psychiatric illness.. Cambridge: Cambridge University Press; 1997;
  14. Nemiah JC, Freyberger H, Sifneos PE. Alexithymia: a view of the psychosomatic process. In:  Hill OW editors. Modern Trends in Psychosomatic Medicine. vol 3:London: Butterworths; 1976;p. 430–439
  15. Grabe HJ, Spitzer C, Freyberger HJ. Alexithymia and the temperament and character model of personality. Psychother Psychosom. 2001;70:261–267
  16. Jula A, Salminen JK, Saarijarvi S. Alexithymia: a facet of essential hypertension. Hypertension. 1999;33:1057–1061
  17. Nordby G, Ekeberg O, Knardahl S, Os I. A double-blind study of psychosocial factors in 40-year-old women with essential hypertension. Psychother Psychosom. 1995;63:142–150
  18. Todarello O, Taylor GJ, Parker JD, Fanelli M. Alexithymia in essential hypertensive and psychiatric outpatients: a comparative study. J Psychosom Res. 1995;39:987–994
  19. John U, Greiner B, Hensel E, Ludemann J, Piek M, Sauer S, et al. Study of Health In Pomerania (SHIP): a health examination survey in an east German region: objectives and design. Soz Praventivmed. 2001;46:186–194
  20. Spalletta G, Pasini A, Costa A, De Angelis D, Ramundo N, Paolucci S, et al. Alexithymic features in stroke: effects of laterality and gender. Psychosom Med. 2001;63:944–950
  21. Kojima M, Frasure-Smith N, Lesperance F. Alexithymia following myocardial infarction: psychometric properties and correlates of the Toronto Alexithymia Scale. J Psychosom Res. 2001;51:487–495
  22. Bach M, Bach D, de Zwaan M, Serim M, Bohmer F. Validation of the German version of the 20-item Toronto Alexithymia Scale in normal persons and psychiatric patients. Psychother Psychosom Med Psychol. 1996;46:23–28
  23. Wittchen H, Höfler M, Gander F, Pfister H, Storz S. Screening for mental disorders: performance of the Composite International Diagnostic-Screener (CID-S). Int J Meth Psychiat Res. 1999;59–70
  24. Rothman KJ. Using regression models in epidemiologic analyses. In: Epidemiology: An Introduction. Oxford: Oxford University Press; 2002;p. 181–197
  25. Long JS, Freeze J. Regression models for categorical dependent variables using Stata. 2nd ed.. College Station (Tex): Stata Press. StataCorp LP; 2006;
  26. Rothman K. Spreadsheets for the analyses of epidemiologic data. http://www.oup.com/us/companion.websites/0195135547/downloads/?view=usa2004;
  27. Schafer JL, Graham JW. Missing data: our view of the state of the art. Psychol Methods. 2002;7:147–177
  28. Arnold AM, Kronmal RA. Multiple imputation of baseline data in the cardiovascular health study. Am J Epidemiol. 2003;157:74–84
  29. Schafer JL. Analysis of incomplete multivariate data. New York: Chapman & Hall; 1997;
  30. Kauhanen J, Kaplan GA, Cohen RD, Salonen R, Salonen JT. Alexithymia may influence the diagnosis of coronary heart disease. Psychosom Med. 1994;56:237–244
  31. Rothman KJ. What is causation?. In: Epidemiology: An Introduction. Oxford: Oxford University Press; 2002;p. 11
  32. Bunker SJ, Colquhoun DM, Esler MD, Hickie IB, Hunt D, Jelinek VM, et al. “Stress” and coronary heart disease: psychosocial risk factors. Med J Aust. 2003;178:272–276
  33. Honkalampi K, Hintikka J, Koivumaa-Honkanen H, Antikainen R, Haatainen K, Viinamaki H. Long-term alexithymic features indicate poor recovery from depression and psychopathology. A six-year follow-up. Psychother Psychosom. 2007;76:312–314
  34. Grabe HJ, Ruhrmann S, Ettelt S, Muller A, Buhtz F, Hochrein A, et al. Alexithymia in obsessive-compulsive disorder — results from a family study. Psychother Psychosom. 2006;75:312–318
  35. Jorgensen MM, Zachariae R, Skytthe A, Kyvik K. Genetic and environmental factors in alexithymia: a population-based study of 8,785 Danish twin pairs. Psychother Psychosom. 2007;76:369–375
  36. Joukamaa M, Kokkonen P, Veijola J, Laksy K, Karvonen JT, Jokelainen J, et al. Social situation of expectant mothers and alexithymia 31 years later in their offspring: a prospective study. Psychosom Med. 2003;65:307–312
  37. Spitzer C, Brandl S, Rose HJ, Nauck M, Freyberger HJ. Gender-specific association of alexithymia and norepinephrine/cortisol ratios. A preliminary report. J Psychosom Res. 2005;59:73–76
  38. Beresnevaite M. Exploring the benefits of group psychotherapy in reducing alexithymia in coronary heart disease patients: a preliminary study. Psychother Psychosom. 2000;69:117–122
  39. Grabe HJ, Frommer J, Ankerhold A, Ulrich C, Gröger R, Franke GH, et al. Alexithymia and outcome in psychotherapy. Psychother Psychosom. 2008;77:189–194

☆ The work is part of the Community Medicine Research Net of the University of Greifswald, Germany, which is funded by the Federal Ministry of Education and Research (grant no. ZZ9603), the Ministry of Cultural Affairs, as well as the Social Ministry of the Federal State of Mecklenburg-West Pomerania.

☆☆ There are no conflicts of interest. See Appendix A for financial support in the past 3 years.

PII: S0022-3999(09)00280-3

doi: 10.1016/j.jpsychores.2009.07.015

Journal of Psychosomatic Research
Volume 68, Issue 2 , Pages 139-147 , February 2010

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