Journal of Psychosomatic Research
Volume 68, Issue 1 , Pages 73-81 , January 2010

Stress profile, coping style, anxiety, depression, and gastric emptying as predictors of functional dyspepsia: A case-control study

  • José Ma. De la Roca-Chiapas

      Affiliations

    • División de Ciencias e Ingenierías, Departamento de Ingeniería Física, Universidad de Guanajuato, León, Guanajuato, México
    • Asociación Cultural Nueva Acrópolis México, León, Guanajuato, México
    • Corresponding Author InformationCorresponding author. Tel.: +52 477 7885100x8475; fax: +52 477 7885100x8410.
  • ,
  • Silvia Solís-Ortiz

      Affiliations

    • División de Ciencias de la Salud, Departamento de Ciencias Médicas, Universidad de Guanajuato, León, Guanajuato, México
  • ,
  • Martha Fajardo-Araujo

      Affiliations

    • División de Ciencias de la Salud, Departamento de Ciencias Médicas, Universidad de Guanajuato, León, Guanajuato, México
  • ,
  • Modesto Sosa

      Affiliations

    • División de Ciencias e Ingenierías, Departamento de Ingeniería Física, Universidad de Guanajuato, León, Guanajuato, México
  • ,
  • Teodoro Córdova-Fraga

      Affiliations

    • División de Ciencias e Ingenierías, Departamento de Ingeniería Física, Universidad de Guanajuato, León, Guanajuato, México
  • ,
  • Alma Rosa-Zarate

      Affiliations

    • Instituto Mexicano del Seguro Social, León, Guanajuato, México

Received 11 August 2008 ,Revised 3 May 2009 ,Accepted 26 May 2009.

References 

  1. Malagelada JR. Functional dyspepsia. Insights on mechanisms and management strategies.. Gastroenterol Clin Noth Am. 1996;25:103–112
  2. Tack J, Bisschops R, Sarnelli G. Pathophysiology and treatment of functional dyspepsia. Gastroenterology. 2004;127:1239–1255
  3. Drossman DA, Li Z, Andruzzi E, Temple RD, Talley NJ, Thompson WG, et al. U.S. householder survey of functional gastrointestinal disorders. Prevalence, sociodemography, and health impact. Dig Dis Sci. 1993;38:1569–1580
  4. Shaib Y, El-Serag HB. The prevalence and risk factors of functional dyspepsia in a multiethnic population in the United States. Am J Gastroenterol. 2004;99:2210–2216
  5. Mahadeva S, Goh KL. Epidemiology of functional dyspepsia: a global perspective. World J Gastroenterol. 2006;12:2661–2666
  6. Talley NJ, Locke GR, Lahr BD, Zinsmeister AR, Tougas G, Ligozio G, et al. Functional dyspepsia, delayed gastric emptying, and impaired quality of life. Gut. 2006;55:933–939
  7. De Vries DR, Van Herwaarden MA, Baron A, Smout AJ, Samsom M. Concomitant functional dyspepsia and irritable bowel syndrome decrease health-related quality of life in gastroesophageal reflux disease. Scand J Gastroenterol. 2007;42:951–956
  8. Talley NJ, Zinsmeister AR, Schleck CD, Melton LJ. Dyspepsia and dyspepsia subgroups: a population-based study. Gastroenterology. 1992;102:1259–1268
  9. Castillo EJ, Camilleri M, Locke GR, Burton DD, Stephens DA, Geno DM, et al. A Community-based controlled study of the epidemiology and pathophysiology of dyspepsia. Clin Gastroenterol Hepatol. 2004;2:985–996
  10. Choung RS, Talley NJ. Novel mechanisms in functional dyspepsia. World J Gastroenterol. 2006;12:676–677
  11. Taché Y, Martinez V, Million M, Wang L. Stress and the gastrointestinal tract: III. Stress-related alterations of gut motor function: role of brain corticotropin-releasing factor receptors. Am J Physiol Gastrointest Liver Physiol. 2001;280:G173–177
  12. Cheng C, Hui WM, Lam SK. Psychosocial factors and perceived severity of functional dyspeptic symptoms: a psychosocial interactionist model. Psychosom Med. 2004;66:85–91
  13. Jorgensen LS, Bonlokke L, Christensen NJ. Life strain, life events, and autonomic response to a psychological stressor in patients with chronic upper abdominal pain. Scand J Gastroenterol. 1986;21:605–613
  14. Locke GR, Weaver AL, Melton LJ, Talley NJ. Psychosocial factors are linked to functional gastrointestinal disorders: a population based nested case-control study. Am J Gastroenterol. 2004;99:350–357
  15. Chen TS, Lee YC, Chang FY, Wu HC, Lee SD. Psychosocial distress is associated with abnormal gastric myoelectrical activity in patients with functional dyspepsia. Scand J Gastroenterol. 2006;41:791–796
  16. Hefeiz HB, Al-Quorain A, Al-Mangoor S, Karim AA. Life events stress in functional dyspepsia: a case control study. Eur J Gastroenterol Hepatol. 1997;9:21–26
  17. Jones MP, Sharp LK, Crowell MD. Psychosocial correlates of symptoms in functional dyspepsia. Clin Gastroenterol Hepatol. 2005;3:521–528
  18. Stam R, Croiset G, Akkermans LM, Wiegant VM. Effects of novelty and conditioned fear on small intestinal and colonic and behavior in the rat. Physiol Behav. 1995;58:803–809
  19. Rao SS, Hatfield RA, Suls JM, Chamberlain MJ. Psychological and physical stress induce differential effects on human colonic motility. Am J Gastroenterol. 1998;93:985–990
  20. Mönnikes H, Tebbe JJ, Hildebrandt M, Arck P, Osmanoglou E, Rose M, et al. Role of stress in functional gastrointestinal disorders. Evidence for stress-induced alterations in gastrointestinal motility and sensitivity. Dig Dis. 2001;19:201–211
  21. Malagelada JR. Gastrointestinal motor disturbances in functional dyspepsia. Scand J Gastroenterol. 1991;182:29–32
  22. Maes DB, Ghoos YF, Hiele MI, Rutgeerts PJ. Gastric emptying rate of solids in patients with nonulcer dyspepsia. Dig Dis Sci. 1997;42:1158–1162
  23. Wilhelmsen I. Somatization, sensitization, and functional dyspepsia. Scand J Psychol. 2002;43:177–180
  24. Scott AM, kellow JE, Shuter B, Cowan H, Corbett AM, Riley JW, et al. Intragastric distribution and gastric emptying of solids and liquids in functional dyspepsia. Lack of influence of symptoms subgroups and H. pylori associated gastritis. Dig Dis Sci. 1993;38:2247–2254
  25. Konskenpato J, Kairemo K, Korppi-Tommola T, Farkkila M. Role of gastric emptying in functional dyspepsia: a scintigraphic study of 94 subjects. Dig Dis Sci. 1998;43:1154–1158
  26. Kirschbaum C, Hellhammer DH. Salivary cortisol in psychoneuroendocrine research: recent developments and applications. Psychoneuroendocrinology. 1994;19:313–333
  27. Taché Y, Bonaz B. Corticotropin-releasing factor receptors and stress-related alterations of gut motor function. J Clin Invest. 2007;117:33–40
  28. Ehlert U, Nater UM, Böhmelt A. High and low unstimulated salivary cortisol levels correspond to different symptoms of functional gastrointestinal disorders. J Psychosom Res. 2005;59:7–10
  29. Barry S, Dinan TG. Functional dyspepsia: are psychosocial factors of relevance?. World J Gastroenterol. 2006;12:2701–2707
  30. Drossman DA, Creed FH, Olden KW, Svedlund J, Toner BB, Whitehead WE. Psychosocial aspects of the functional gastrointestinal disorders. Gut. 1999;45(Suppl 2):II:25–II:30
  31. Henningsen P, Zimmermann T, Sattel H. Medically unexplained physical symptoms, anxiety, and depression: a meta-analytic. Psychosom Med. 2003;65:528–533
  32. Magni G, di Mario F, Bernasconi G, Mastropaolo G. DSM-III diagnosis associated with dyspepsia of unknown cause. Am J Psychiatry. 1987;144:1222–1223
  33. Haug TT, Svebak S, Hausken T, Wilhemsen I, Berstad A, Ursin H. Low vagal activity as mediating mechanism for the relationship between personality factors and gastric symptoms in functional dyspepsia. Psychosom Med. 1994;56:181–186
  34. Hu WH, Wong WM, Lam KF, Hui WM, Lai KC, Xia HX, et al. Anxiety but not depression determines health care-seeking behavior in Chinese patients with dyspepsia and irritable bowel syndrome: a population based study. Aliment Pharmacol Ther. 2002;16:2081–2088
  35. Tominaga K, Higuchi K, Iketani T, Ochi M, Kadouchi K, Tanigawa T, et al. Comparison of gastrointestinal symptoms and psychological factors of functional dyspepsia to peptic ulcer or panic disorder patients. Inflammopharmacology. 2007;15:84–89
  36. Van Oudenhove L, Vandenberghe J, Geeraerts B, Vos R, Persoons P, Demyttenaere K, et al. Relationship between anxiety and gastric sensorimotor function in functional dyspepsia. Psychosom Med. 2007;69:455–463
  37. Lorena SL, Tinois E, Brunetto SQ, Camargo EE, Mesquita MA. Gastric emptying and intragastric distribution of a solid meal in functional dyspepsia: influence of gender and anxiety. J Clin Gastroenterol. 2004;38:230–236
  38. Haag S, Senf W, Häuser W, Tagay S, Grandt D, Heuft G, et al. Impairment of health-related quality of life in functional dyspepsia and chronic liver disease: the influence of depression and anxiety. Aliment Pharmacol Ther. 2008;27:561–571
  39. Chou LT, Wu CY, Chen HP, Chang CS, Wong PG, Ko CW, et al. The correlation of depression and gastric dysrhythmia in functional dyspepsia. J Clin Gastroenterol. 2001;33:127–131
  40. Azevedo da Silva R, Tavares Pinheiro R, Azevedo da Silva R, Lessa Horta B, Moraes I, Duarte Faria A. Dispepsia funcional e depressão como fator asociado. Arq Gastroenterol. 2006;43:293–298
  41. Welén K Faresjö A, Faresjö T. Functional dyspepsia affects women more than men in daily life: a case-control study in primary care. Gend Medicine. 2008;5:62–73
  42. Van Oudenhove L, Vandenberghe J, Geeraerts B, Vos R, Persoons P, Fischler B, et al. Determinants of symptoms in functional dyspepsia: gastric sensorimotor function, psychosocial factors or somatisation?. Gut. 2008;57:1666–1676
  43. Talley NJ, Stanghellini V, Heading RC, Koch KL, Malagelada JR, Tytgat GN. Functional gastroduodenal disorders. Gut. 1999;45:II37–II42
  44. Cordova-Fraga T, Bernal-Alvarado JJ, Gutierrez-Juarez G, Sosa M, Vargas-Luna M. Gastric activity studies using a magnetic tracer. Physiol Meas. 2004;25:1261–1270
  45. Jenks WG, Thomas MI, Wikswo JP. Squids encyclopedia. Appl Phys. 1997;19:457–468
  46. De la Roca-Chiapas JM, Córdova T, Hernández E, Solorio S, Solís S, Sosa M. Magnetogastrography (MGG) reproducibility assessments of gastric emptying on healthy subjects. Physiol Meas. 2007;28:175–183
  47. Nowack KM. Manual del Perfil del Estrés. México:: Manual Moderno; 2002;
  48. Spielberg CD, Gorsuch Rl, Lushene RE. Manual for the State-Trait Anxiety Inventory. California: Consulting Psychologists Press; 1970;
  49. Spielberg CD, Martínez-Urrutia A, Gonzalez-Reigosa F, Palacio L, Díaz-Guerrero R. Inventario de Autoevaluación (IDARE). México: Manual Moderno; 1980;
  50. Beck AT, Sleer RA. Beck Depression Inventory. Texas: The Psychological Corporation; 1993;
  51. Jurado S, Villegas ME, Méndez L, Rodríguez F, Loperena V, Varela R. La estandarización del Inventario de Depresión de Beck para los residentes de la ciudad de México. Salud Mental. 1998;21:26–31
  52. Creelman CD, Donaldson W. ROC curves for discrimination of linear extent. J Exp Psychol. 1968;77:514–516
  53. Mizuta Y, Shikuwa S, Isomoto H, Mishima R, Akazawa Y, Masuda J, et al. Recent insights into digestive motility in functional dyspepsia. J Gastroenterol. 2006;41:1025–1040
  54. Mayer EA. The neurobiology of stress and gastrointestinal disease. Gut. 2000;47:861–869
  55. Lee S, Park M, Choi S, Nah Y, Abbey SE, Rodin G. Stress, coping, and depression in non-ulcer dyspepsia patients. J Psychosom Res. 2000;49:93–99
  56. Bennett E, Beaurepaire J, Langeluddecke P, Kellow J, Tennant C. Life stress and non-ulcer dyspepsia: a case-control study. J Psychosom Res. 1991;35:579–590
  57. Kirschbaum C, Hellhammer DH. Salivary cortisol in psychobiological research. Neuropsychology. 1989;22:150–169
  58. Kudielka BM, Schommer NC, Hellhammer DH, Kirschbaum C. Acute HPA axis responses, heart rate, and mood changes to psychosocial stress (TSST) in humans at different times of day. Psychoneuroendocrinology. 2004;29:983–992
  59. Jones MP, Maganti K. Symptoms, gastric function and psychosocial factors in functional dyspepsia. J Clin Gastroenterol. 2004;38:866–872
  60. Geeraerts B, Vandenberghe J, Van Oudenhove L, Gregory LJ, Aziz Q, Dupont P, et al. Influence of experimentally induced anxiety on gastric sensorimotor function in humans. Gastroenterology. 2005;129:1437–1444
  61. Lazarus RS. From psychological stress to the emotions: a history of changing outlooks. Annu Rev Psychol. 1993;44:1–21
  62. Chan DW. The Chinese Ways of Coping Questionnaire: assessing coping in secondary school teachers and students in Hong Kong. Psychol Assess. 1994;6:108–116
  63. Ursin H, Eriksen HR. The cognitive activation theory of stress. Psychoneuroendocrinology. 2004;29:567–592
  64. Cheng C, Hui WM, Lam SK. Coping style of individuals with functional dyspepsia. Psychosom Med. 1999;61:789–795
  65. Keohane J, Quigley EMM. Functional dyspepsia: the role of visceral hypersensitivity in its pathogenesis. World Gastroenterol. 2006;12:2672–2676
  66. Camilleri M, Coulie B, Tack JF. Visceral hypersensitivity: facts, speculations, and challenges. Gut. 2001;48:125–131
  67. Vandenberghe J, Vos R, Persoons P, Demyttenaere K, Janssens J, Tack J. Dyspeptic patients with visceral hypersensitivity: sensitisation of pain specific or multimodal pathways?. Gut. 2005;54:914–919
  68. Ladabaum U, Minoshima S, Hasler WL, Cross D, Chey WD, Owyang C. Gastric distention correlates with activation of multiple cortical and subcortical regions. Gastroenterology. 2001;120:369–376

 This work was supported by CONACyT Grant 38749-E, CONCyTEG Grant 0316k118-028, and by the University of Guanajuato. José Maria de la Roca received a CONACyT scholarship (No. 184928) for work on a doctorate degree and a dissertation scholarship (CONCyTEG No. 06-16-k119-16).

PII: S0022-3999(09)00192-5

doi: 10.1016/j.jpsychores.2009.05.013

Journal of Psychosomatic Research
Volume 68, Issue 1 , Pages 73-81 , January 2010