Journal of Psychosomatic Research
Volume 58, Issue 2 , Pages 115-120 , February 2005

Endogenous opiates and the placebo effect: A meta-analytic review

  • Marie D. Sauro

      Affiliations

    • Department of Psychology, University of Massachusetts Dartmouth, 285 Old Westport Road, North Dartmouth, MA 02747, United States
    • Corresponding Author InformationCorresponding author. Tel.: +1 508 999 8380
    • ,
  • Roger P. Greenberg

      Affiliations

    • Department of Psychiatry, State University of New York Upstate Medical University, Syracuse, NY, United States

Received 15 March 2004 ,Accepted 7 July 2004.

References 

  1. Shapiro AK, Shapiro E. The powerful placebo: from ancient priest to modern physician. Baltimore: Johns Hopkins Univ. Press; 1997;
  2. Quitkin FM. Placebos, drug effects, and study design: a clinician's guide. Am J Psychiatry. 1999;156:829–836
  3. Hrobjartsson A, Gotzsche PC. Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment. N Engl J Med. 2001;344(21):1594–1602
  4. Benedetti F. How the doctor's words affect the patient's brain. Eval Health Prof. 2002;25(4):369–386
  5. Starfield B, Wray C, Hess K, Gross R, Birk PS, D'Lugoff BC. The influence of patient–practitioner agreement on outcome of care. Am J Publ Health. 1981;71:127–132
  6. Shetty N, Friedman JH, Keiburtz K, Marshall FJ, Oakes D. The placebo response in Parkinson's disease. Parkinson study group. Clin Neuropharmacol. 1999;22:207–212
  7. Greenberg RP, Bornstein RF, Greenberg MD, Fisher S. A meta-analysis of antidepressant outcome under “blinder” conditions. J Consult Clin Psychol. 1992;60(5):664–669
  8. Greenberg RP, Fisher S. Mood-mending medicines: probing drug, psychotherapy, and placebo solutions. In:  Fisher S,  Greenberg RP editor. From placebo to panacea: putting psychiatric drugs to the test. New York: Wiley; 1997;p. 115–172
  9. Mayberg HS, Silva JA, Brannan SK, Tekell JL, Mahurin RK, McGinnis S, et al. The functional neuroanatomy of the placebo effect. Am J Psychiatry. 2002;159(5):728–737
  10. Petrovic P, Kalso E, Petersson KM, Ingvar M. Placebo and opioid analgesia—imaging a shared neural network. Science. 2002;295:1737–1740
  11. Leuchter AF, Cook IA, Witte EA, Morgan M, Abrams M. Changes in brain function of depressed subjects during treatment with placebo. Am J Psychiatry. 2002;159:122–129
  12. Levine JD, Gordon NC, Fields HL. The mechanism of placebo analgesia. Lancet. 1978;654–657
  13. Benedetti F. The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia. Pain. 1996;64:535–543
  14. Grevert P, Albert LH, Goldstein A. Partial antagonism of placebo analgesia by naloxone. Pain. 1983;16:129–143
  15. de la Fuente-Fernandez R, Stoessl AJ. The biochemical bases for reward: implications for the placebo effect. Eval Health Prof. 2002;25:387–398
  16. Benedetti F, Amanzio M. The neurobiology of placebo analgesia: from endogenous opioids to cholecystokinin. Prog Neurobiol. 1997;51:109–125
  17. ter Riet G, de Craen AJM, de Boer A, Kessels AGH. Is placebo analgesia mediated by endogenous opioids? A systematic review. Pain. 1998;76:273–275
  18. Cohen J. Statistical power analysis for the behavioral sciences. New York: Academic Press; 1969;
  19. Johnson BT. DSTAT: software for the meta-analytic review of research literatures. Hillsdale (NJ): Erlbaum; 1989;
  20. Rosenthal R, Rubin D. Meta-analytic procedures for combining studies with multiple effect sizes. Psychol Bull. 1986;99:400–406
  21. Hedges LV, Olkin I. Statistical methods for meta-analysis. Orlando: Academic Press; 1985;
  22. Wolf FM. Meta-analysis: quantitative methods of research synthesis. Newbury Park: Sage Publications; 1986;
  23. Benschop RJ, Geenen R, Mills PJ, Naliboff BD, Kiecolt-Glaser JK, Herbert TB, et al. Cardiovascular and immune responses to acute psychological stress in young and old women: a meta-analysis. Psychosom Med. 1998;60:290–296
  24. Jorgensen RS, Johnson BT, Kolodzeij ME, Schreer GE. Elevated blood pressure and personality: a meta-analytic review. Psychol Bull. 1996;120:293–320
  25. Rossy LA, Buckelew SP, Dorr N, Haggland KJ, Thayer JF, McIntosh MJ, et al. A meta-analysis of fibromyalgia treatment interventions. Ann Behav Med. 1999;21:180–191
  26. Rosenthal R. The “file-drawer” problem and tolerance for null results. Psychol Bull. 1979;86:638–641
  27. Orwin RG. A fail-safe N for effect size. J Educ Stat. 1983;8:157–159
  28. Beecher HK. Relationship of significance of wound to pain experienced. J Am Med Assoc. 1956;161:1609–1613
  29. Amanzio M, Benedetti F. Neuropharmacological dissection of placebo analgesia: expectation-activated opioid systems versus conditioning-activated subsystems. J Neurosci. 1999;19:484–494
  30. Price DD, Soerensen LV. Endogenous opioid and non-opioid pathways as mediators of placebo analgesia. In:  Guess HA,  Kleinman A,  Kusek JW,  Engel LW editor. The science of the placebo. London: BMJ Books; 2002;p. 183–206
  31. Price DD, Milling LS, Kirsch I, Duff A, Montgomery GH, Nicholls SS. An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm. Pain. 1999;83:147–156
  32. Brody H. The placebo response: recent research and implications for family medicine. J Fam Pract. 2000;49(7):649–654
  33. Wager TD, Rilling JK, Smith EE, Sokolik A, Casey KL, Davidson RJ, et al. Placebo-induced changes in fMRI in the anticipation and experience of pain. Science. 2004;303:1162–1167
  34. Lipman JJ, Miller BE, Mays KS, Miller MN, North WC, Byrne WL. Peak beta endorphin concentration in cerebrospinal fluid: reduced in chronic pain patients and increased during the placebo response. Psychopharmacology. 1990;102:112–116
  35. Roelofs J, ter Riet G, Peters ML, Kessels AGH, Ruelen JPH, Menheere PPCA. Expectations of analgesia do not affect nociceptive R-III reflex activity: an experimental study into the mechanism of placebo-induced analgesia. Pain. 2000;89:75–80
  36. Kirsch I. The placebo effect: an interdisciplinary exploration. Cambridge (MA): Harvard Univ. Press; 1999;
  37. Houston BK. Personality dimensions in reactivity and cardiovascular disease. New York: Wiley; 1986;

PII: S0022-3999(04)00515-X

doi: 10.1016/j.jpsychores.2004.07.001

Journal of Psychosomatic Research
Volume 58, Issue 2 , Pages 115-120 , February 2005

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